Mendelian randomization analysis reveals higher whole body water mass may increase risk of bacterial infections.

ABSTRACT:

Background and purpose

The association of water loading with several infections remains unclear. Observational studies are hard to investigate definitively due to potential confounders. In this study, we employed Mendelian randomization (MR) analysis to assess the association between genetically predicted whole body water mass (BWM) and several infections.

Methods

BWM levels were predicted among 331,315 Europeans in UK Biobank using 418 SNPs associated with BWM. For outcomes, we used genome-wide association data from the UK Biobank and FinnGen consortium, including sepsis, pneumonia, intestinal infections, urinary tract infections (UTIs) and skin and soft tissue infections (SSTIs). Inverse-variance weighted MR analyses as well as a series of sensitivity analyses were conduct

SUBMITTER: Yan P 

PROVIDER: S-EPMC11232203 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature