Clinical and genomic features of Mycobacterium avium complex: a multi-national European study.

ABSTRACT:

Background

The Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently includes twelve species. M. avium (MAV), M. intracellulare subsp. intracellulare (MINT), and M. intracellulare subsp. chimaera (MCH) are clinically most relevant. However, the population structure and genomic landscape of MAC linked with potential pathobiological differences remain little investigated.

Methods

Whole genome sequencing (WGS) was performed on a multi-national set of MAC isolates from Germany, France, and Switzerland. Phylogenetic analysis was conducted, as well as plasmids, resistance, and virulence genes predicted from WGS data. Data was set into a global context with publicly available sequences. Finally, detailed cli

SUBMITTER: Wetzstein N 

PROVIDER: S-EPMC11232273 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature