High variance in quantification of Mycobacterium tuberculosis at low bacterial loads and with differentially detectable mycobacteria.

ABSTRACT: We examined the correlation between three different methods of Mycobacterium tuberculosis quantification: time to positivity (TTP), log₁₀ CFU, and an assay to detect differentially detectable M. tuberculosis (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb (P < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.

SUBMITTER: Walsh KF 

PROVIDER: S-EPMC11232379 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature