In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections.
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SUBMITTER: Reidenberg BE
PROVIDER: S-EPMC11232392 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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<i>In vitro</i> activity of taurolidine against clinical <i>Candida auris</i> isolates: relevance to catheter-related bloodstream infections.
Reidenberg Bruce E BE Jenkins Stephen G SG Crandon Jared L JL Hurlburt Elizabeth E Tan Xing X Rhomberg Paul R PR Arends S J Ryan SJR Pfaffle Antony A
Antimicrobial agents and chemotherapy 20240612 7
<i>Candida auris</i> is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 <i>C</i>. <i>auris</i> isolates. Taurolidine was highly active with a MIC<sub>50</sub>/MIC<sub>90</sub> of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for ...[more]
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