Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study.

ABSTRACT:

Introduction

Idiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs. In this study, the concentrations of 196 lipid metabolites and nitrogen oxide (NO) production in the cerebrospinal fluid (CSF) and plasma of dogs with MUO or IE were measured using a LC-MS/MS and a NOx analyzer, respectively.

Methods

Nine clinically healthy dogs and 11 and 12 dogs with IE and MUO, respectively, were included in the study.

Results

Lipid analysis revealed variations in the levels of four and six lipid metabolites in CSF and plasma, respectively, between the groups. The levels of 6-keto-prostaglandin (PG) F1_α (PGF1_α), 20-carboxy arachidonic acid (20-carboxy-AA), 9-hydroxyoctadeca

SUBMITTER: Yonezawa T 

PROVIDER: S-EPMC11232469 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature