Psychosocial stressors and breast cancer gene expression in the Black Women's Health Study.

ABSTRACT:

Purpose

Prior studies indicate that the physiologic response to stress can affect gene expression. We evaluated differential gene expression in breast cancers collected from Black women with high versus low exposure to psychosocial stressors.

Methods

We analyzed tumor RNA sequencing data from 417 Black Women's Health Study breast cancer cases with data on early life trauma and neighborhood disadvantage. We conducted age-adjusted differential gene expression analyses and pathway analyses. We also evaluated Conserved Transcriptional Response to Adversity (CTRA) contrast scores, relative fractions of immune cell types, T cell exhaustion, and adrenergic signaling. Analyses were run separately for estrogen receptor positive (ER+; n = 299) and ER- (n = 118) cases.

Results

A

SUBMITTER: Barnard ME 

PROVIDER: S-EPMC11232497 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature