Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.

ABSTRACT:

Background

Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, in mediating the relationships between OSA, intestinal barrier dysfunction and systemic inflammation.

Methods

Two hundred and thirty-five male participants who complained with sleep problems and underwent whole night polysomnography at our sleep centre between 2017 and 2018 were enrolled. Polysomnographic data, anthropometric measurements and biochemical indicators were collected. Serum melatonin, intestinal barrier function biomarker zonula occludens-1 (ZO-1) and inflammatory biomarkers C-reactive protein (CRP) with lipopolysaccharide (LPS) were detected. Spearman's correlation analysi

SUBMITTER: Wei Z 

PROVIDER: S-EPMC11232642 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature