Long-term neuropsychological outcomes of deep brain stimulation in early-stage Parkinson's disease.

ABSTRACT:

Introduction

The pilot trial of deep brain stimulation (DBS) in early-stage Parkinson's disease (PD) randomized 30 patients (medication duration 0.5-4 years; without dyskinesia or motor fluctuations) to receive optimal drug therapy alone (early ODT) or subthalamic nucleus (STN) DBS plus ODT (early DBS + ODT). This study reports long-term neuropsychological outcomes from the early DBS pilot trial.

Methods

This is an extension of an earlier study that examined two-year neuropsychological outcomes in the pilot trial. The primary analysis was conducted on the five-year cohort (n = 28), and a secondary analysis was conducted on the 11-year cohort (n = 12). Linear mixed effects models for each analysis compared overall trend in outcomes for randomization groups. All subjects who c

SUBMITTER: Hacker ML 

PROVIDER: S-EPMC11232874 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature