Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells.

ABSTRACT:

Background

Doxorubicin is an effective chemotherapeutic agent, but its use is limited by acute and chronic cardiotoxicity. Exercise training has been shown to protect against doxorubicin-induced cardiotoxicity, but the involvement of immune cells remains unclear. This study aimed to investigate the role of exercise-derived B cells in protecting against doxorubicin-induced cardiotoxicity and to further determine whether B cell activation and antibody secretion play a role in this protection.

Methods

Mice that were administered with doxorubicin (5 mg/kg per week, 20 mg/kg cumulative dose) received treadmill running exercise. The adoptive transfer of exercise-derived splenic B cells to μMT^-/- (B cell-deficient) mice was performed to elucidate the mechanism of B cell

SUBMITTER: Wang J 

PROVIDER: S-EPMC11233173 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature