Estimating the Effect of Radical Prostatectomy: Combining Data From the SPCG4 and PIVOT Randomized Trials With Contemporary Cohorts.

ABSTRACT:

Purpose

Two randomized trials (SPCG4 and PIVOT) have compared surgery to conservative management for localized prostate cancer. The applicability of these trials to contemporary practice remains uncertain. We aimed to develop an individualized prediction model for prostate cancer mortality comparing immediate surgery at a high-volume center to active surveillance.

Materials and methods

We determined whether the relative risk of prostate cancer mortality with surgery vs observation varied by baseline risk. We then used various estimates of relative risk to estimate 15-year mortality with and without surgery using, as a predictor, risk of biochemical recurrence calculated from a model.

Results

We saw no evidence that relative risk varied by baseline risk, supporting the

SUBMITTER: Vickers A 

PROVIDER: S-EPMC11233245 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature