Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT₇ Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells.

ABSTRACT: There is some evidence that the serotonin receptor subtype 7 (5-HT₇) could be new therapeutic target for neuroprotection. The aim of this study was to compare the neuroprotective and neurite outgrowth potential of new 5-HT₇ receptor agonists (AH-494, AGH-238, AGH-194) with 5-CT (5-carboxyamidotryptamine) in human neuroblastoma SH-SY5Y cells. The results revealed that 5-HT₇ mRNA expression was significantly higher in retinoic acid (RA)-differentiated cells when compared to undifferentiated ones and it was higher in cell cultured in neuroblastoma experimental medium (DMEM) compared to those placed in neuronal (NB) medium. Furthermore, the safety profile of compounds was favorable for all tested compounds at concentration used for neuroprotection evaluation (u

SUBMITTER: Jakubowska K 

PROVIDER: S-EPMC11233329 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature