Gait asymmetry and symptom laterality in Parkinson's disease: two of a kind?

ABSTRACT:

Background

The laterality of motor symptoms is considered a key feature of Parkinson's disease (PD). Here, we investigated whether gait and turning asymmetry coincided with symptom laterality as determined by the MDS-UPRDS part III and whether it was increased compared to healthy controls (HC).

Methods

We analyzed the asymmetry of gait and turning with and without a cognitive dual task (DT) using motion capture systems and wearable sensors in 97 PD patients mostly from Hoehn & Yahr stage II and III and 36 age-matched HC. We also assessed motor symptom asymmetry using the bilateral sub-items of the MDS-UPDRS-III. Finally, we examined the strength of the association between gait asymmetry and symptom laterality.

Results

Participants with PD had increased gait but not mo

SUBMITTER: Seuthe J 

PROVIDER: S-EPMC11233399 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature