Genomic and biological insights of bacteriophages JNUWH1 and JNUWD in the arms race against bacterial resistance.

ABSTRACT: The coevolution of bacteria and bacteriophages has created a great diversity of mechanisms by which bacteria fight phage infection, and an equivalent diversity of mechanisms by which phages subvert bacterial immunity. Effective and continuous evolution by phages is necessary to deal with coevolving bacteria. In this study, to better understand the connection between phage genes and host range, we examine the isolation and genomic characterization of two bacteriophages, JNUWH1 and JNUWD, capable of infecting Escherichia coli. Sourced from factory fermentation pollutants, these phages were classified within the Siphoviridae family through TEM and comparative genomic analysis. Notably, the phages exhibited a viral burst size of 500 and 1,000 PFU/cell, with latent periods of 15 a

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11233448 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature