Oculomotor atypicalities in motor neurone disease: a systematic review.

ABSTRACT:

Introduction

Cognitive dysfunction is commonplace in Motor Neurone Disease (MND). However, due to the prominent motor symptoms in MND, assessing patients' cognitive function through traditional cognitive assessments, which oftentimes require motoric responses, may become increasingly challenging as the disease progresses. Oculomotor pathways are apparently resistant to pathological degeneration in MND. As such, abnormalities in oculomotor functions, largely driven by cognitive processes such as saccades and smooth pursuit eye movement, may be reflective of frontotemporal cognitive deficits in MND. Thus, saccadic and smooth pursuit eye movements may prove to be ideal mechanistic markers of cognitive function in MND.

Methods

To ascertain the utility of saccadic and smooth purs

SUBMITTER: Readman MR 

PROVIDER: S-EPMC11233471 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature