High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades.

ABSTRACT:

Background

Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and accelerated T2 mapping methods based on echo merging and using k-t undersampling and reduced flip angles (TEMPURA) and tested their potential to quantify differences between renal tumour subtypes and grades.

Methods

Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC). Median, kurtosis, and skewness of T2 were quantified in tumours and in the normal-ad

SUBMITTER: Horvat-Menih I 

PROVIDER: S-EPMC11233479 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature