Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Backgrounds

Current observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated. Consequently, this study is designed to evaluate the causal interconnection between ankylosing spondylitis and cardiovascular-related conditions utilizing a bidirectional two-sample Mendelian Randomization (MR) methodology.

Methods

In this study, we conducted Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. The fixed-effects inverse variance weighted (IVW) model was used as the primary analysis method, and MR-Egger regression and the weighted median method were employed as supplementary approaches. Horizontal pleiotropy and heterogeneity we

SUBMITTER: Liu P 

PROVIDER: S-EPMC11233527 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature