Regulation of anti-phage defense mechanisms by using cinnamaldehyde as a quorum sensing inhibitor.

ABSTRACT:

Background

Multidrug-resistant bacteria and the shortage of new antibiotics constitute a serious health problem. This problem has led to increased interest in the use of bacteriophages, which have great potential as antimicrobial agents but also carry the risk of inducing resistance. The objective of the present study was to minimize the development of phage resistance in Klebsiella pneumoniae strains by inhibiting quorum sensing (QS) and thus demonstrate the role of QS in regulating defense mechanisms.

Results

Cinnamaldehyde (CAD) was added to K. pneumoniae cultures to inhibit QS and thus demonstrate the role of the signaling system in regulating the anti-phage defense mechanism. The QS inhibitory activity of CAD in K. pneumoniae was confirmed by a redu

SUBMITTER: Barrio-Pujante A 

PROVIDER: S-EPMC11233531 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature