Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption.

ABSTRACT: Regeneration, the ability to replace injured tissues and organs, is a phenomenon commonly associated with lower vertebrates but is also observed in mammals, in specific tissues. In this study, we investigated the regenerative potential of pancreatic islets following moderate beta-cell loss in mice. Using a rapid model of moderate ablation, we observed a compensatory response characterized by transient inflammation and proliferation signatures, ultimately leading to the recovery of beta-cell identity and function. Interestingly, this proliferative response occurred independently of inflammation, as demonstrated in ablated immunodeficient mice. Furthermore, exposure to high-fat diet stimulated beta-cell proliferation but negatively impacted beta-cell function. In contrast, an equivalent slow

SUBMITTER: Mathisen AF 

PROVIDER: S-EPMC11233560 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature