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Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma.

ABSTRACT: Recent studies indicate that Glypican 1 (GPC-1) is aberrantly expressed and plays a key role in certain cancers, but little is known in the hepatocellular carcinoma. Raw data from TCGA, GTEx and TIMER databases were utilized to comprehensively analyze GPC-1 expression landscape in pan-cancer, and the biological function of GPC-1 was investigated in liver cancer cells. The results revealed that GPC-1 is highly expressed in HCC, negatively correlated with survival, and also positively correlated with immune infiltration and clinical stage. Furthermore, GPC-1 promoted cell proliferation and inhibited apoptosis in the HCC cell lines. WGCNA analysis and HCCDB database revealed that Akt acted as a key molecule related to GPC-1, influencing biological functions and regulating cell malignant behaviors via the AKT signaling pathway. In conclusion, our findings provide a relatively comprehensive understanding of the oncogenic role of GPC-1 in HCC, implying that GPC-1 could serve as an innovative therapeutic target.

SUBMITTER: Cao L

PROVIDER: S-EPMC11233571 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma.

Cao Li L Li Fang F Cai Shuang S Zhang Jinyuan J Guo Chen C Ali Sadiq S Zhou Jing J Jing Xintao X Wang Xiaofei X Qin Yannan Y Wu Fei F

Scientific reports 20240709 1

Recent studies indicate that Glypican 1 (GPC-1) is aberrantly expressed and plays a key role in certain cancers, but little is known in the hepatocellular carcinoma. Raw data from TCGA, GTEx and TIMER databases were utilized to comprehensively analyze GPC-1 expression landscape in pan-cancer, and the biological function of GPC-1 was investigated in liver cancer cells. The results revealed that GPC-1 is highly expressed in HCC, negatively correlated with survival, and also positively correlated w ...[more]

PMID: 38982153

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Dataset Information

Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma.

Publications

Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma.

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