A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC11233613 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
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A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma.
Chen Juan J Zhang Cheng-Hui CH Tao Tao T Zhang Xian X Lin Yan Y Wang Fang-Bin FB Liu Hui-Fang HF Liu Jian J
Communications biology 20240709 1
Aberrant RNA editing has emerged as a pivotal factor in the pathogenesis of hepatocellular carcinoma (HCC), but the impact of RNA co-editing within HCC remains underexplored. We used a multi-step algorithm to construct an RNA co-editing network in HCC, and found that HCC-related RNA editings are predominantly centralized within the network. Furthermore, five pairs of risk RNA co-editing events were significantly correlated with the overall survival in HCC. Based on presence of risk RNA co-editin ...[more]
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