Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity.

ABSTRACT: 45S5 Bioglass (BG) is composed of a glass network with silicate based on the component and can be doped with various therapeutic ions for the enhancement of hard tissue therapy. Nanoceria (CeO₂) has been shown to indicate redox reaction and enhance the biological response. However, few studies focus on the proportion of CeO₂-doped and its effect on the cellular bioactivity of CeO₂-doped BG (CBG). In this study, we synthesized the CBG series with increasing amounts of doping CeO₂ ranging (1 to 12) wt.%. The synthesized CBG series examined the characterization, mineralization capacity, and cellular activity against BG. Our results showed that the CBG series exhibited a glass structure and indicated the redox states between Ce³⁺ and Ce

SUBMITTER: Ryu JH 

PROVIDER: S-EPMC11233629 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature