Human red blood cells express the RNA sensor TLR7.
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ABSTRACT:
SUBMITTER: Metthew Lam LK
PROVIDER: S-EPMC11233670 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Publications
Human red blood cells express the RNA sensor TLR7.
Metthew Lam L K LK Oatman Emily E Eckart Kaitlyn A KA Klingensmith Nathan J NJ Flowers Emily E Sayegh Layal L Yuen Julia J Clements Rebecca L RL Meyer Nuala J NJ Jurado Kellie A KA Vaughan Andrew E AE Eisenbarth Stephanie C SC Mangalmurti Nilam S NS
Scientific reports 20240709 1
Red blood cells (RBCs) express the nucleic acid-binding toll-like receptor 9 (TLR9) and bind CpG-containing DNA. However, whether human RBCs express other nucleic acid-binding TLRs is unknown. Here we show that human RBCs express the RNA sensor TLR7. TLR7 is present on the red cell membrane and is associated with the RBC membrane protein Band 3. In patients with SARS-CoV2-associated sepsis, TLR7-Band 3 interactions in the RBC membrane are increased when compared with healthy controls. In vitro, ...[more]
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