Effects of ankylosing spondylitis on cardiovascular disease: aMendelian randomization study.

ABSTRACT:

Objective

Accumulating evidence suggests that patients with ankylosing spondylitis (AS) have an elevated risk for cardiovascular disease (CVD) and cardiovascular death, however, whether AS has causal effects on the risk of CVD is unclear.Two-sample Mendelian randomization (MR) was utilizedto examine the probable causal link between them.

Methods

Summary statistics from publicly released genome-wide association studies (GWAS) was used to perform MR analyses. Genetically predicted AS was selected as the exposure variable from published GWAS meta-analyses. CVD was adopted as the outcome variable. The inverse variant weighted method was employed to obtain the casual estimates. The robustness of the results was also examined by evaluating the pleiotropy and heterogeneity of singl

SUBMITTER: Xiao L 

PROVIDER: S-EPMC11233707 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature