HLA variants and their association with IgE-Mediated banana allergy: A cross-sectional study.

ABSTRACT:

Background

Banana allergy is on the rise in tropical regions. Advances in genomics and candidate gene identification have increased interest in genetic factors in food allergies. However, the genetic basis of IgE-mediated banana allergy is underexplored.

Objective

To characterize HLA variants and their association with IgE-mediated banana allergy.

Methods

This cross-sectional study recruited banana-allergic adults, confirmed by allergology tests, with non-allergic individuals as controls. Genomic DNA extraction and sequencing BAM files for HLA typing were conducted. Allele frequency was calculated using the direct counting method, and odds ratio (OR) with 95 % confidence interval (CI) were determined. Fisher's exact or chi-square tests were used to assess associations

SUBMITTER: Vichara-Anont I 

PROVIDER: S-EPMC11233952 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature