Casual relationships between circulating metabolites and rheumatoid arthritis: A mendelian randomization study.

ABSTRACT:

Background

Blood metabolites serve as pivotal indicators in identifying and predicting the course of rheumatoid arthritis (RA). However, empirical substantiation of a direct causal link between these serum biomarkers and the development of RA is still lacking comprehensive support.

Method

In pursuit of a thorough exploration of the causal links between circulating blood metabolites and RA, we deployed a two-sample Mendelian randomization (MR) approach during our initial investigative phase. This method was utilized to examine the potential connections between 249 distinct circulating metabolites and the prevalence of RA. In the validation phase, we conducted replication analyses with a new metabolic dataset consisting of 123 metabolites. Furthermore, we employed the Mendelia

SUBMITTER: An G 

PROVIDER: S-EPMC11234099 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature