METTL3 regulates thyroid cancer differentiation and chemosensitivity by modulating PAX8.

ABSTRACT: Background: Thyroid cancer (TC) is a common endocrine cancer with a favourable prognosis. However, poor patient prognosis due to TC dedifferentiation is becoming an urgent challenge. Recently, methyltransferase-like 3 (METTL3)-mediated N⁶ -methyladenosine (m⁶A) modification has been demonstrated to play an important role in the occurrence and progression of various cancers and a tumour suppressor role in TC. However, the mechanism of METTL3 in TC remains unclear. Methods: The correlation between METTL3 and prognosis in TC patients was evaluated by immunohistochemistry. Mettl3^fl/flBraf^V600ETPO-cre TC mouse models and RNA-seq were used to investigate the underlying molecular mechanism, which was further validated by i

SUBMITTER: Kang N 

PROVIDER: S-EPMC11234206 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature