Ontology highlight
ABSTRACT:
SUBMITTER: Gao W
PROVIDER: S-EPMC11234323 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Gao William W Yang Ann A Rivas Elena E
IUBMB life 20221210 6
Covariation induced by compensatory base substitutions in RNA alignments is a great way to deduce conserved RNA structure, in principle. In practice, success depends on many factors, importantly the quality and depth of the alignment and the choice of covariation statistic. Measuring covariation between pairs of aligned positions is easy. However, using covariation to infer evolutionarily conserved RNA structure is complicated by other extraneous sources of covariation such as that resulting fro ...[more]