A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks.

ABSTRACT: Embryo development is a dynamic process governed by the regulation of timing and sequences of gene expression, which control the proper growth of the organism. Although many genetic programmes coordinating these sequences are common across species, the timescales of gene expression can vary significantly among different organisms. Currently, substantial experimental efforts are focused on identifying molecular mechanisms that control these temporal aspects. In contrast, the capacity of established mathematical models to incorporate tempo control while maintaining the same dynamical landscape remains less understood. Here, we address this gap by developing a mathematical framework that links the functionality of developmental programmes to the corresponding gene expression orbits (or landsc

SUBMITTER: Manser CL 

PROVIDER: S-EPMC11234385 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature