H₂S Increases Blood Pressure via Activation of L-Type Calcium Channels with Mediation by HS^• Generated from Reactions with Oxyhemoglobin.

ABSTRACT: Although the gasotransmitter hydrogen sulfide (H₂S) is well known for its vasodilatory effects, H₂S also exhibits vasoconstricting properties. Herein, it is demonstrated that administration of H₂S as intravenous sodium sulfide (Na₂S) increased blood pressure in sheep and rats, and this effect persisted after H₂S has disappeared from the blood. Inhibition of the L-type calcium channel (LTCC) diminished the hypertensive effects. Incubation of Na₂S with whole blood, red blood cells, methemoglobin, or oxyhemoglobin produced a hypertensive product of H₂S, which is not hydrogen thioperoxide, metHb-SH^- complexes, per-/poly- sulfides, or thiolsulfate, but rather a labile intermediate. One-electron oxidation of

SUBMITTER: Liu T 

PROVIDER: S-EPMC11234399 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature