An evaluation of sample size requirements for developing risk prediction models with binary outcomes.

ABSTRACT: Risk prediction models are routinely used to assist in clinical decision making. A small sample size for model development can compromise model performance when the model is applied to new patients. For binary outcomes, the calibration slope (CS) and the mean absolute prediction error (MAPE) are two key measures on which sample size calculations for the development of risk models have been based. CS quantifies the degree of model overfitting while MAPE assesses the accuracy of individual predictions. Recently, two formulae were proposed to calculate the sample size required, given anticipated features of the development data such as the outcome prevalence and c-statistic, to ensure that the expectation of the CS and MAPE (over repeated samples) in models fitted using MLE will meet prespeci

SUBMITTER: Pavlou M 

PROVIDER: S-EPMC11234534 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature