Development of a prognostic risk model of uveal melanoma based on N7-methylguanosine-related regulators.

ABSTRACT:

Background

Uveal melanoma (UVM) stands as the predominant type of primary intraocular malignancy among adults. The clinical significance of N7-methylguanosine (m7G), a prevalent RNA modifications, in UVM remains unclear.

Methods

Primary information from 80 UVM patients were analyzed as the training set, incorporating clinical information, mutation annotations and mRNA expression obtained from The Cancer Genome Atlas (TCGA) website. The validation set was carried out using Gene Expression Omnibus (GEO) database GSE22138 and GSE84976. Kaplan-Meier and Cox regression of univariate analyses were subjected to identify m7G-related regulators as prognostic genes.

Result

A prognostic risk model comprising EIF4E2, NUDT16, SNUPN and WDR4 was established through Cox regression o

SUBMITTER: Wu P 

PROVIDER: S-EPMC11234703 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature