Effects and mechanisms of puerarin against neuroblastoma: insights from bioinformatics and in vitro experiments.

ABSTRACT:

Background

Neuroblastoma, a prevalent solid tumor in children, often manifests with hidden onset sites, rapid growth, and high metastatic potential. The prognosis for children with high-risk neuroblastoma remains poor, highlighting the urgent need for novel prognostic models and therapeutic avenues. In recent years, puerarin, as a kind of small molecule drug extracted from Chinese medicine Pueraria lobata, has demonstrated significant anticancer effects on various cancer cell types. In this study, through bioinformatics analysis and in vitro experiments, the potential and mechanism of puerarin in the treatment of neuroblastoma were investigated, and a prognostic model was established.

Methods

A total of 9 drug-disease related targets were observed by constructing a database

SUBMITTER: Sui X 

PROVIDER: S-EPMC11234716 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature