Long-term cardiovascular inflammation and fibrosis in a murine model of vasculitis induced by <i>Lactobacillus casei</i> cell wall extract.

ABSTRACT:

Background

Kawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of coronary artery aneurysms (CAA) in affected children, which may persist for months and even years after the acute phase of the disease. There is an unmet need to characterize the immune and pathological mechanisms of the long-term complications of KD.

Methods

We examined cardiovascular complications in the Lactobacillus casei cell wall extract (LCWE) mouse model of KD-like vasculitis over 4 months. The long-term immune, pathological, and functional changes occurring in cardiovascular lesions were characterized by histological examination, flow cytometric analysis, immu

SUBMITTER: Lombardi Pereira AP 

PROVIDER: S-EPMC11234797 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature