Evolutionary and co-evolutionary phage training approaches enhance bacterial suppression and delay the emergence of phage resistance.

ABSTRACT: The development of phage resistance by bacteria is a major barrier that impedes the therapeutic use of phages. Phage training has been proposed as a novel tool that harnesses the evolutionary potential of phages to improve phage infectivity. Both evolutionary and co-evolutionary phage training models have been previously reported to train phages. However, both of these phage training models have been reported able to effectively suppress the emergence of phage-resistant bacteria mutants, thus presenting a contradictory phenomenon. Therefore, in this study, we set out to systematically compare the effectiveness of both evolutionary and co-evolutionary phage training models with regard to phage physiology, infectivity, and genotype. To this end, a natural lytic phage capable of infecting a <

SUBMITTER: Ngiam L 

PROVIDER: S-EPMC11234896 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature