Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans.

ABSTRACT: Repeated mild traumatic brain injury is of growing interest regarding public and sporting safety and is thought to have greater adverse or cumulative neurological effects when compared with single injury. While epidemiological links between repeated traumatic brain injury and outcome have been investigated in humans, exploration of its mechanistic substrates has been largely undertaken in animal models. We compared acute neurological effects of repeat mild traumatic brain injury (n = 21) to that of single injury (n = 21) and healthy controls (n = 76) using resting-state functional MRI and quantified thalamic functional connectivity, given previous identification of its prognostic potential in human mild traumatic brain injury and rodent repeat mild traumatic brain inju

SUBMITTER: Woodrow RE 

PROVIDER: S-EPMC11235327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature