Relationship between brain white matter damage and grey matter atrophy in hereditary spastic paraplegia types 4 and 5.

ABSTRACT:

Background and purpose

White matter (WM) damage is the main target of hereditary spastic paraplegia (HSP), but mounting evidence indicates that genotype-specific grey matter (GM) damage is not uncommon. Our aim was to identify and compare brain GM and WM damage patterns in HSP subtypes and investigate how gene expression contributes to these patterns, and explore the relationship between GM and WM damage.

Methods

In this prospective single-centre cohort study from 2019 to 2022, HSP patients and controls underwent magnetic resonance imaging evaluations. The alterations of GM and WM patterns were compared between groups by applying a source-based morphometry approach. Spearman rank correlation was used to explore the associations between gene expression and GM atrophy patterns

SUBMITTER: Tu Y 

PROVIDER: S-EPMC11235729 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature