Disease spectrum of myopathies with elevated aldolase and normal creatine kinase.

ABSTRACT:

Background and purpose

Elevation of serum creatine kinase (CK) or hyperCKemia is considered a biological marker of myopathies. However, selective elevation of serum aldolase with normal CK has been reported in a few myopathies, including dermatomyositis, immune-mediated myopathy with perimysial pathology and fasciitis with associated myopathy. The aim was to investigate the disease spectrum of myopathies with isolated aldolase elevation.

Methods

Medical records were reviewed to identify patients >18 years old seen between December 1994 and June 2020 who had pathologically proven myopathies with elevated aldolase and normal CK level. Patients with alternative causes of aldolase elevation were excluded.

Results

Thirty-four patients with various types of myopathies were

SUBMITTER: Soontrapa P 

PROVIDER: S-EPMC11235866 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature