Symptom-based staging for logopenic variant primary progressive aphasia.

ABSTRACT:

Background and purpose

Logopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction across AD phenotypes. A clinical staging system is lacking for the evolution of AD-associated communication difficulties that could guide diagnosis and care planning. Our aim was to create a symptom-based staging scheme for lvPPA, identifying functional milestones relevant to the broader AD spectrum.

Methods

An international lvPPA caregiver cohort was surveyed on symptom development under an 'exploratory' survey (34 UK caregivers). Feedback from this survey informed the development of a 'consolidation' survey (27 UK, 10 Australian caregivers) in which caregivers were presented with si

SUBMITTER: Hardy CJD 

PROVIDER: S-EPMC11235891 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature