Celery-derived scaffolds with liver lobule-mimicking structures for tissue engineering transplantation.

ABSTRACT: Decellularized scaffolds have a demonstrated value in liver tissue engineering. Challenges in this area are focused on effectively eliminating the biological rejection of scaffolds and finding a suitable liver cell source. Here, inspired by the natural microstructure of hepatic lobules, we present a novel decellularized celery-derived scaffold cultured with human-induced pluripotent stem cell-derived hepatocytes (hiPSC-Heps) bioengineering liver tissue construction. Because of the natural hollow channels, interconnected porous structures, and excellent physicochemical characterization of the decellularized celery-derived scaffold, the resultant bioengineering liver tissue can maintain the hiPSC-Heps viability and the hepatic functions in the in vitro cultures. Based on this bioengineering

SUBMITTER: Wang J 

PROVIDER: S-EPMC11236025 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature