Monitoring silica core@shell nanoparticle-bacterial film interactions using the multi-parametric surface plasmon resonance technique.

ABSTRACT: In a healthcare setting, biofilms are a major source of infection and difficult to eradicate once formed. Nanoparticles (NPs) can be designed to effectively penetrate biofilms to more efficiently either deliver antibiotic drugs throughout the biofilm matrix or elicit inherent antibiofilm activity. Antibacterial cerium oxide (CeO₂) NPs were employed as core material and coated with a mesoporous silica shell (MSN) to generate cerium oxide coated mesoporous silica NPs (CeO₂@MSN). Detailed studies of NP-biofilm interactions are required to rationally develop NP platforms to prevent biofilm-related infections. This work developed and implemented a unique label-free analysis platform for the real-time monitoring of bacterial biofilm formation and then assessed the interacti

SUBMITTER: Mustafa RA 

PROVIDER: S-EPMC11236032 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature