Photothermal-enhanced in situ supramolecular hydrogel promotes bacteria-infected wound healing in diabetes.

ABSTRACT: Bacterial infection can impede the healing of chronic wounds, particularly diabetic wounds. The high-sugar environment of diabetic wounds creates a favorable condition for bacterial growth, posing a challenge to wound healing. In clinical treatment, the irregular shape of the wound and the poor mechanical properties of traditional gel adjuvants make them susceptible to mechanical shear and compression, leading to morphological changes and fractures, and difficult to adapt to irregular wounds. Traditional gel adjuvants are prepared in advance, while in situ gel is formed at the site of administration after drug delivery in a liquid state, which can better fit the shape of the wound. Therefore, this study developed an in situ HA/GCA/Fe²⁺-GOx gel using a photothermal-enhanced Fento

SUBMITTER: Zheng C 

PROVIDER: S-EPMC11236056 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature