Prioritizing drug targets by perturbing biological network response functions.

ABSTRACT: Therapeutic interventions are designed to perturb the function of a biological system. However, there are many types of proteins that cannot be targeted with conventional small molecule drugs. Accordingly, many identified gene-regulatory drivers and downstream effectors are currently undruggable. Drivers and effectors are often connected by druggable signaling and regulatory intermediates. Methods to identify druggable intermediates therefore have general value in expanding the set of targets available for hypothesis-driven validation. Here we identify and prioritize potential druggable intermediates by developing a network perturbation theory, termed NetPert, for response functions of biological networks. Dynamics are defined by a network structure in which vertices represent genes and pr

SUBMITTER: Perrone MC 

PROVIDER: S-EPMC11236158 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature