Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models.

ABSTRACT:

Objectives

The aim of this systematic review article is to evaluate the relationship between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal models. The review focused on studies assessing SNHL in diabetic animal models, elucidating the mechanisms of DM-associated SNHL, and exploring the response of diabetic animal models to noise overexposure. We also discussed studies investigating the efficacy of potential therapeutic strategies for amelioration of DM-associated SNHL in the animal models.

Methods

A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42023439961). We conducted a comprehensive search on PubMed, Science Direct, Web of Science, Scopus, and EMBAS

SUBMITTER: Mittal R 

PROVIDER: S-EPMC11236185 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature