The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer.

ABSTRACT:

Background

Cuproptosis is a type of cell death characterized by excessive copper-lipid reactions in the tricarboxylic acid cycle, resulting in protein toxicity stress and cell death. Although known as a cuproptosis inhibitor through CRISPR-Cas9 screening, the role of cyclin-dependent kinase inhibitor 2A (CDKN2A) in cuproptosis resistance and its connection to tumor development remains unclear.

Methods

In this study, we combined single-cell sequencing, spatial transcriptomics, pathological image analysis, TCGA multi-omics analysis and in vitro experimental validation to comprehensively investigate CDKN2A distribution, expression, epigenetic modification, regulation and genomic features in colorectal cancer cells. We further explored the associations between CDKN2A and

SUBMITTER: Cheng X 

PROVIDER: S-EPMC11236303 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature