Hereditary Gastric Cancer Is Linked With Hereditary Breast and Ovarian Cancer.

ABSTRACT:

Background

Helicobacter pylori (H. pylori), a bacterium which chronically infects the stomach of approximately half the world's population, is a risk factor for the development of gastric cancer (GC). However, the underlying mechanism whereby H. pylori infection induces GC development remains unclear. Intermittent injection of the H. pylori cytotoxin-associated gene A antigen (CagA) protein into its host cell inhibits nuclear translocation of BRCA1/BRCA2, DNA repair proteins involved in the development of breast cancer/ovarian cancer. Interestingly, hereditary breast and ovarian cancer (HBOC) syndrome is associated with GC development. Here, we aimed to clarify the molecular link between H. pylori infection, BRCA1/2 pathogenic variants (PVs

SUBMITTER: Hayashi T 

PROVIDER: S-EPMC11236378 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature