Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.

ABSTRACT: Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in high-density extracellular electrophysiology recording probes, such as Neuropixels, provide a promising avenue to accomplish this goal. Identifying the same neurons in multiple recordings is, however, complicated by non-rigid movement of the tissue relative to the recording sites (drift) and loss of signal from some neurons. Here, we propose a neuron tracking method that can identify the same cells independent of firing statistics, that are used by most existing methods. Our method is based on between-day non-rigid alignment of spike-sorted clusters. We verified the same cell identity in mice using measured visual receptive fields. This

SUBMITTER: Yuan AX 

PROVIDER: S-EPMC11236416 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature