From psoriasis to psoriatic arthritis: epidemiological insights from a retrospective cohort study of 74,046 patients.

ABSTRACT:

Introduction

To verify our hypothesis that psoriatic arthritis (PsA) is mainly genetically predetermined and distinct from psoriasis (PsO), we use the TriNetX database to investigate whether intrinsic factors outweigh externals in PsA emergence in PsO patients.

Methods

We conducted three retrospective cohort studies utilizing information from the TriNetX network, whether (a) PsO patients with type 2 diabetes mellitus (DM) face an elevated risk of developing PsA compared to those without type 2 DM; (b) PsO patients who smoke face a higher risk of PsA; and (c) PsO patients with type 2 DM who smoke are more likely to develop PsA than those who do not smoke.

Results

PsO patients with type 2 DM exhibited an elevated risk of developing PsA [hazard ratio (HR), 1.11; 95% CI 1

SUBMITTER: Huo AP 

PROVIDER: S-EPMC11236760 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature