Increased blood CSF3R⁺ myeloid-derived suppressor cell is a predictor for breast cancer recurrence.

ABSTRACT: Early detection of cancer recurrence using specific biomarkers remains a clinically unmet need, although methodologies for monitoring tumor markers, cell-free DNA, and circulating tumor cells have been established for decades. Tumor recurrence develops in metastatic or dormant cancer cells under continuous immune surveillance. Alterations in the population and function of immune cells may contribute to cancer recurrence. Here, we utilized an animal model to imitate breast tumor recurrence after surgical resection and investigated the abundance and gene expression profiles of immune cells using NanoString analysis. Bioinformatic analysis of a published single-cell RNA sequencing database of myeloid-derived suppressor cells (MDSCs) was performed to identify common targets between the two stu

SUBMITTER: Li YL 

PROVIDER: S-EPMC11236774 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature