Efficacy comparison of high-genetic barrier nucleos(t)ide analogues in treatment-naive chronic hepatitis B patients: a network meta-analysis.

ABSTRACT:

Background/aims

Four high-genetic barrier nucleos(t)ide analogues (NAs) for chronic hepatitis B (CHB), namely entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), and besifovir dipivoxil maleate (BSV), have been established. The aim of this study is to investigate the efficacy of four high-genetic barrier NAs using a network meta-analysis of randomized trials and propensity score-matched cohorts.

Methods

Systematic search was performed using PubMed, Cochrane library, and EMBASE and included randomized controlled trials and cohort studies that used propensity score matching. Studies on treatment-naïve CHB patients treated with ETV, TDF, TAF, or BSV were included. Outcomes included alanine aminotransferase normalization and hepatitis B e antigen s

SUBMITTER: Lee J 

PROVIDER: S-EPMC11236812 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature