Increasing correlation between oral and gastric microbiota during gastric carcinogenesis.

ABSTRACT:

Background/aims

Recent research has increasingly focused on the role of the gastric microbiome in the development of gastric cancer. We aimed to investigate the changes in the microbiome during gastric carcinogenesis in structural and functional aspects, with a specific focus on the association between oral and gastric microbiomes.

Methods

We collected saliva, gastric juice, and gastric tissue samples from 141 patients at different stages of gastric carcinogenesis and processed them for microbiome analysis using 16S rRNA gene profiling. The alpha and beta diversities were analyzed, and the differences in microbiome composition and function profiles were analyzed among the groups, as well as the correlation between changes in the oral and gastric microbiomes during carcinogen

SUBMITTER: You HS 

PROVIDER: S-EPMC11236816 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature